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KMID : 1004820100110030161
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Journal of Biomedical Research
2010 Volume.11 No. 3 p.161 ~ p.165
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Potent Inhibition of Vitexin on the Serum-Stimulated Vascular Smooth Muscle Cell Proliferation
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Lim Yong
Yun Yeo-Pyo
Pyo Hyeong-Bae
Lee Mi-Yea
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Abstract
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Atherosclerosis, a disease of the large arteries, is the primary cause of heart disease and stroke. The abnormal proliferation of vascular smooth muscle cells (VSMCs) in arterial walls is an important pathogenetic factor of vascular disorders like atherosclerosis and restenosis after angioplasty. In the current study, the possible anti-proliferative effect of vitexin originated from Acer palmatum was investigated in rat aortic VSMCs. Vitexin was found to potently inhibit 5% fetal bovine serum (FBS)-induced growth of VSMCs. Pre-treatment with vitexin (5-50 μg/ml) in VSMCs for 24 h resulted in a significant decrease in cell number, i.e., the inhibition rates were 5.4±7.1, 52.5±8.4, and 78.9±5.2% with vitexin treatments of 5, 20, and 50 μg/ml, respectively. In addition, trteatment with vitexin resulted in significant and dose-dependent inhibition of 5% FBS-induced DNA synthesis. Vitexin did not show any cytotoxicity in rat aortic VSMCs under this experimental condition. These results indicate the potential for development of vitexin as an anti-proliferative agent for treatment of angioplasty restenosis and atherosclerosis.
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KEYWORD
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Vitexin, Atherosclerosis, Proliferation, Vascular smooth muscle cell
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